Impact of dietary and obesity genetic risk scores on weight gain.

Détails

ID Serval
serval:BIB_3D45D9B2B0E1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Impact of dietary and obesity genetic risk scores on weight gain.
Périodique
The American journal of clinical nutrition
Auteur⸱e⸱s
Baratali L., Mean M., Marques-Vidal P.
ISSN
1938-3207 (Electronic)
ISSN-L
0002-9165
Statut éditorial
Publié
Date de publication
02/08/2021
Peer-reviewed
Oui
Volume
114
Numéro
2
Pages
741-751
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Whether genetic background and/or dietary behaviors influence weight gain in middle-aged subjects is debated.
To assess whether genetic background and/or dietary behaviors are associated with changes in obesity markers (BMI, weight, and waist and hip circumferences) in a Swiss population-based cohort.
Cross-sectional and prospective (follow-up of 5.3 y) study. Two obesity genetic risk scores (GRS) based on 31 or 68 single nucleotide polymorphisms were used. Dietary intake was assessed using a semiquantitative FFQ. Three dietary patterns "Meat & fries" (unhealthy), "Fruits & vegetables" (healthy), and "Fatty & sugary" (unhealthy), and 3 dietary scores (2 Mediterranean and the Alternative Healthy Eating Index [AHEI]) were computed.
On cross-sectional analysis (N = 3033, 53.2% females, 58.4 ± 10.6 y), obesity markers were positively associated with unhealthy dietary patterns and GRS, and negatively associated with healthy dietary scores and patterns. On prospective analysis (N = 2542, 54.7% females, age at baseline 58.0 ± 10.4 y), the AHEI and the "Fruits & vegetables" pattern were negatively associated with waist circumference gain: multivariate-adjusted average ± SE 0.96 ± 0.25 compared with 0.11 ± 0.26 cm (P for trend 0.044), and 1.14 ± 0.26 compared with -0.05 ± 0.26 cm (P for trend 0.042) for the first and fourth quartiles of the AHEI and the "Fruits & vegetables" pattern, respectively. Similar inverse associations were obtained for changes in waist >5 cm: multivariate-adjusted OR (95% CI): 0.65 (0.50, 0.85) and 0.67 (0.51, 0.89) for the fourth versus the first quartile of the AHEI and the "Fruits & vegetables" dietary pattern, respectively. No associations were found between GRS and changes in obesity markers, and no significant gene-diet interactions were found.
Dietary intake, not GRS, are associated with waist circumference in middle-aged subjects living in Lausanne, Switzerland.
Mots-clé
Aged, Cross-Sectional Studies, Diet/adverse effects, Diet/standards, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Obesity/genetics, Weight Gain/genetics, dietary intake, gene-diet interactions, obesity, prospective study, weight gain
Pubmed
Web of science
Création de la notice
04/05/2021 8:34
Dernière modification de la notice
11/09/2021 5:39
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