Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
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State: Public
Version: Supplementary document
License: Not specified
Serval ID
serval:BIB_C6C6C43DAEB1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
Journal
Nature genetics
Working group(s)
23andMe Research Team, COGENT (Cognitive Genomics Consortium), Social Science Genetic Association Consortium
Contributor(s)
Agee M., Alipanahi B., Auton A., Bell R.K., Bryc K., Elson S.L., Fontanillas P., Hinds D.A., McCreight J.C., Huber K.E., Litterman N.K., McIntyre M.H., Mountain J.L., Noblin E.S., Northover CAM, Pitts S.J., Sathirapongsasuti J.F., Sazonova O.V., Shelton J.F., Shringarpure S., Tian C., Vacic V., Wilson C.H., Okbay A., Beauchamp J.P., Fontana M.A., Lee J.J., Pers T.H., Rietveld C.A., Turley P., Chen G.B., Emilsson V., Meddens SFW, Oskarsson S., Pickrell J.K., Thom K., Timshel P., Vlaming R., Abdellaoui A., Ahluwalia T.S., Bacelis J., Baumbach C., Bjornsdottir G., Brandsma J.H., Concas M.P., Derringer J., Furlotte N.A., Galesloot T.E., Girotto G., Gupta R., Hall L.M., Harris S.E., Hofer E., Horikoshi M., Huffman J.E., Kaasik K., Kalafati I.P., Karlsson R., Kong A., Lahti J., van der Lee S.J., Leeuw C., Lind P.A., Lindgren K.O., Liu T., Mangino M., Marten J., Mihailov E., Miller M.B., van der Most P.J., Oldmeadow C., Payton A., Pervjakova N., Peyrot W.J., Qian Y., Raitakari O., Rueedi R., Salvi E., Schmidt B., Schraut K.E., Shi J., Smith A.V., Poot R.A., St Pourcain B., Teumer A., Thorleifsson G., Verweij N., Vuckovic D., Wellmann J., Westra H.J., Yang J., Zhao W., Zhu Z., Alizadeh B.Z., Amin N., Bakshi A., Baumeister S.E., Biino G., Bønnelykke K., Boyle P.A., Campbell H., Cappuccio F.P., Davies G., De Neve J.E., Deloukas P., Demuth I., Ding J., Eibich P., Eisele L., Eklund N., Evans D.M., Faul J.D., Feitosa M.F., Forstner A.J., Gandin I., Gunnarsson B., Halldórsson B.V., Harris T.B., Heath A.C., Hocking L.J., Holliday E.G., Homuth G., Horan M.A., Hottenga J.J., de Jager P.L., Joshi P.K., Jugessur A., Kaakinen M.A., Kähönen M., Kanoni S., Keltigangas-Järvinen L., Kiemeney LALM, Kolcic I., Koskinen S., Kraja A.T., Kroh M., Kutalik Z., Latvala A., Launer L.J., Lebreton M.P., Levinson D.F., Lichtenstein P., Lichtner P., Liewald DCM, Loukola LCSA, Madden P.A., Mägi R., Mäki-Opas T., Marioni R.E., Marques-Vidal P., Meddens G.A., McMahon G., Meisinger C., Meitinger T., Milaneschi Y., Milani L., Montgomery G.W., Myhre R., Nelson C.P., Nyholt D.R., Ollier WER, Palotie A., Paternoster L., Pedersen N.L., Petrovic K.E., Porteous D.J., Räikkönen K., Ring S.M., Robino A., Rostapshova O., Rudan I., Rustichini A., Salomaa V., Sanders A.R., Sarin A.P., Schmidt H., Scott R.J., Smith B.H., Smith J.A., Staessen J.A., Steinhagen-Thiessen E., Strauch K., Terracciano A., Tobin M.D., Ulivi S., Vaccargiu S., Quaye L., van Rooij FJA, Venturini C., Vinkhuyzen AAE, Völker U., Völzke H., Vonk J.M., Vozzi D., Waage J., Ware E.B., Willemsen G., Attia J.R., Bennett D.A., Berger K., Bertram L., Bisgaard H., Boomsma D.I., Borecki I.B., Bültmann U., Chabris C.F., Cucca F., Cusi D., Deary I.J., Dedoussis G.V., van Duijn C.M., Eriksson J.G., Franke B., Franke L., Gasparini P., Gejman P.V., Gieger C., Grabe H.J., Gratten J., Groenen PJF, Gudnason V., van der Harst P., Hayward C., Hinds D.A., Hoffmann W., Hyppönen E., Iacono W.G., Jacobsson B., Järvelin M.R., Jöckel K.H., Kaprio J., Kardia SLR, Lehtimäki T., Lehrer S.F., Magnusson PKE, Martin N.G., McGue M., Metspalu A., Pendleton N., Penninx BWJH, Perola M., Pirastu N., Pirastu M., Polasek O., Posthuma D., Power C., Province M.A., Samani N.J., Schlessinger D., Schmidt R., Sørensen TIA, Spector T.D., Stefansson K., Thorsteinsdottir U., Thurik A.R., Timpson N.J., Tiemeier H., Tung J.Y., Uitterlinden A.G., Vitart V., Vollenweider P., Weir D.R., Wilson J.F., Wright A.F., Conley D.C., Krueger R.F., Smith G.D., Hofman A., Laibson D.I., Medland S.E., Meyer M.N., Yang J., Johannesson M., Visscher P.M., Esko T., Koellinger P.D., Cesarini D., Benjamin D.J.
ISSN
1546-1718 (Electronic)
ISSN-L
1061-4036
Publication state
Published
Issued date
23/07/2018
Peer-reviewed
Oui
Volume
50
Number
8
Pages
1112-1121
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Abstract
Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11-13% of the variance in educational attainment and 7-10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.
Keywords
Adult, Aged, Aged, 80 and over, Cohort Studies, Educational Status, Female, Genome-Wide Association Study/methods, Humans, Male, Middle Aged, Multifactorial Inheritance, Phenotype, Polymorphism, Single Nucleotide
Pubmed
Web of science
Create date
31/07/2018 11:00
Last modification date
13/01/2024 8:22
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