Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.

Lee, J.J.; Wedow, R.; Okbay, A.; Kong, E.; Maghzian, O.; Zacher, M.; Nguyen-Viet, T.A.; Bowers, P.; Sidorenko, J.; Karlsson Linnér, R.; Fontana, M.A.; Kundu, T.; Lee, C.; Li, H.; Li, R.; Royer, R.; Timshel, P.N.; Walters, R.K.; Willoughby, E.A.; Yengo, L.; Alver, M.; Bao, Y.; Clark, D.W.; Day, F.R.; Furlotte, N.A.; Joshi, P.K.; Kemper, K.E.; Kleinman, A.; Langenberg, C.; Mägi, R.; Trampush, J.W.; Verma, S.S.; Wu, Y.; Lam, M.; Zhao, J.H.; Zheng, Z.; Boardman, J.D.; Campbell, H.; Freese, J.; Harris, K.M.; Hayward, C.; Herd, P.; Kumari, M.; Lencz, T.; Luan, J.; Malhotra, A.K.; Metspalu, A.; Milani, L.; Ong, K.K.; Perry, JRB; Porteous, D.J.; Ritchie, M.D.; Smart, M.C.; Smith, B.H.; Tung, J.Y.; Wareham, N.J.; Wilson, J.F.; Beauchamp, J.P.; Conley, D.C.; Esko, T.; Lehrer, S.F.; Magnusson, PKE; Oskarsson, S.; Pers, T.H.; Robinson, M.R.; Thom, K.; Watson, C.; Chabris, C.F.; Meyer, M.N.; Laibson, D.I.; Yang, J.; Johannesson, M.; Koellinger, P.D.; Turley, P.; Visscher, P.M.; Benjamin, D.J.; Cesarini, D.

doi:10.1038/s41588-018-0147-3

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.

Détails

Télécharger: lee.pdf (1383.77 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0

Document(s) secondaire(s)

Télécharger: Lee 1.pdf (6350.08 [Ko])
Etat: Public
Version: Supplementary document
Licence: Non spécifiée

Télécharger: Lee 2.xlsx (3081.69 [Ko])
Etat: Public
Version: Supplementary document
Licence: CC BY 4.0

ID Serval

serval:BIB_C6C6C43DAEB1

Type

Article: article d'un périodique ou d'un magazine.

Collection

Publications

Institution

UNIL/CHUV

Titre

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.

Périodique

Nature genetics

Auteur⸱e⸱s

Lee J.J., Wedow R., Okbay A., Kong E., Maghzian O., Zacher M., Nguyen-Viet T.A., Bowers P., Sidorenko J., Karlsson Linnér R., Fontana M.A., Kundu T., Lee C., Li H., Li R., Royer R., Timshel P.N., Walters R.K., Willoughby E.A., Yengo L., Alver M., Bao Y., Clark D.W., Day F.R., Furlotte N.A., Joshi P.K., Kemper K.E., Kleinman A., Langenberg C., Mägi R., Trampush J.W., Verma S.S., Wu Y., Lam M., Zhao J.H., Zheng Z., Boardman J.D., Campbell H., Freese J., Harris K.M., Hayward C., Herd P., Kumari M., Lencz T., Luan J., Malhotra A.K., Metspalu A., Milani L., Ong K.K., Perry JRB, Porteous D.J., Ritchie M.D., Smart M.C., Smith B.H., Tung J.Y., Wareham N.J., Wilson J.F., Beauchamp J.P., Conley D.C., Esko T., Lehrer S.F., Magnusson PKE, Oskarsson S., Pers T.H., Robinson M.R., Thom K., Watson C., Chabris C.F., Meyer M.N., Laibson D.I., Yang J., Johannesson M., Koellinger P.D., Turley P., Visscher P.M., Benjamin D.J., Cesarini D.

Collaborateur⸱rice⸱s

23andMe Research Team, COGENT (Cognitive Genomics Consortium), Social Science Genetic Association Consortium

Contributeur⸱rice⸱s

Agee M., Alipanahi B., Auton A., Bell R.K., Bryc K., Elson S.L., Fontanillas P., Hinds D.A., McCreight J.C., Huber K.E., Litterman N.K., McIntyre M.H., Mountain J.L., Noblin E.S., Northover CAM, Pitts S.J., Sathirapongsasuti J.F., Sazonova O.V., Shelton J.F., Shringarpure S., Tian C., Vacic V., Wilson C.H., Okbay A., Beauchamp J.P., Fontana M.A., Lee J.J., Pers T.H., Rietveld C.A., Turley P., Chen G.B., Emilsson V., Meddens SFW, Oskarsson S., Pickrell J.K., Thom K., Timshel P., Vlaming R., Abdellaoui A., Ahluwalia T.S., Bacelis J., Baumbach C., Bjornsdottir G., Brandsma J.H., Concas M.P., Derringer J., Furlotte N.A., Galesloot T.E., Girotto G., Gupta R., Hall L.M., Harris S.E., Hofer E., Horikoshi M., Huffman J.E., Kaasik K., Kalafati I.P., Karlsson R., Kong A., Lahti J., van der Lee S.J., Leeuw C., Lind P.A., Lindgren K.O., Liu T., Mangino M., Marten J., Mihailov E., Miller M.B., van der Most P.J., Oldmeadow C., Payton A., Pervjakova N., Peyrot W.J., Qian Y., Raitakari O., Rueedi R., Salvi E., Schmidt B., Schraut K.E., Shi J., Smith A.V., Poot R.A., St Pourcain B., Teumer A., Thorleifsson G., Verweij N., Vuckovic D., Wellmann J., Westra H.J., Yang J., Zhao W., Zhu Z., Alizadeh B.Z., Amin N., Bakshi A., Baumeister S.E., Biino G., Bønnelykke K., Boyle P.A., Campbell H., Cappuccio F.P., Davies G., De Neve J.E., Deloukas P., Demuth I., Ding J., Eibich P., Eisele L., Eklund N., Evans D.M., Faul J.D., Feitosa M.F., Forstner A.J., Gandin I., Gunnarsson B., Halldórsson B.V., Harris T.B., Heath A.C., Hocking L.J., Holliday E.G., Homuth G., Horan M.A., Hottenga J.J., de Jager P.L., Joshi P.K., Jugessur A., Kaakinen M.A., Kähönen M., Kanoni S., Keltigangas-Järvinen L., Kiemeney LALM, Kolcic I., Koskinen S., Kraja A.T., Kroh M., Kutalik Z., Latvala A., Launer L.J., Lebreton M.P., Levinson D.F., Lichtenstein P., Lichtner P., Liewald DCM, Loukola LCSA, Madden P.A., Mägi R., Mäki-Opas T., Marioni R.E., Marques-Vidal P., Meddens G.A., McMahon G., Meisinger C., Meitinger T., Milaneschi Y., Milani L., Montgomery G.W., Myhre R., Nelson C.P., Nyholt D.R., Ollier WER, Palotie A., Paternoster L., Pedersen N.L., Petrovic K.E., Porteous D.J., Räikkönen K., Ring S.M., Robino A., Rostapshova O., Rudan I., Rustichini A., Salomaa V., Sanders A.R., Sarin A.P., Schmidt H., Scott R.J., Smith B.H., Smith J.A., Staessen J.A., Steinhagen-Thiessen E., Strauch K., Terracciano A., Tobin M.D., Ulivi S., Vaccargiu S., Quaye L., van Rooij FJA, Venturini C., Vinkhuyzen AAE, Völker U., Völzke H., Vonk J.M., Vozzi D., Waage J., Ware E.B., Willemsen G., Attia J.R., Bennett D.A., Berger K., Bertram L., Bisgaard H., Boomsma D.I., Borecki I.B., Bültmann U., Chabris C.F., Cucca F., Cusi D., Deary I.J., Dedoussis G.V., van Duijn C.M., Eriksson J.G., Franke B., Franke L., Gasparini P., Gejman P.V., Gieger C., Grabe H.J., Gratten J., Groenen PJF, Gudnason V., van der Harst P., Hayward C., Hinds D.A., Hoffmann W., Hyppönen E., Iacono W.G., Jacobsson B., Järvelin M.R., Jöckel K.H., Kaprio J., Kardia SLR, Lehtimäki T., Lehrer S.F., Magnusson PKE, Martin N.G., McGue M., Metspalu A., Pendleton N., Penninx BWJH, Perola M., Pirastu N., Pirastu M., Polasek O., Posthuma D., Power C., Province M.A., Samani N.J., Schlessinger D., Schmidt R., Sørensen TIA, Spector T.D., Stefansson K., Thorsteinsdottir U., Thurik A.R., Timpson N.J., Tiemeier H., Tung J.Y., Uitterlinden A.G., Vitart V., Vollenweider P., Weir D.R., Wilson J.F., Wright A.F., Conley D.C., Krueger R.F., Smith G.D., Hofman A., Laibson D.I., Medland S.E., Meyer M.N., Yang J., Johannesson M., Visscher P.M., Esko T., Koellinger P.D., Cesarini D., Benjamin D.J.

ISSN

1546-1718 (Electronic)

ISSN-L

1061-4036

Statut éditorial

Publié

Date de publication

23/07/2018

Peer-reviewed

Oui

Volume

Numéro

Pages

1112-1121

Langue

anglais

Notes

Publication types: Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
Publication Status: epublish

Résumé

Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11-13% of the variance in educational attainment and 7-10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.

Mots-clé

Adult, Aged, Aged, 80 and over, Cohort Studies, Educational Status, Female, Genome-Wide Association Study/methods, Humans, Male, Middle Aged, Multifactorial Inheritance, Phenotype, Polymorphism, Single Nucleotide

URN

urn:nbn:ch:serval-BIB_C6C6C43DAEB11

OAI-PMH

oai:serval.unil.ch:BIB_C6C6C43DAEB1

DOI

10.1038/s41588-018-0147-3

Pubmed

30038396

Web of science

000440423400010

Création de la notice

31/07/2018 11:00