Comprehensive proteomic analysis of JC polyomavirus-infected human astrocytes and their extracellular vesicles.
Details
Serval ID
serval:BIB_5E6A065E798E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comprehensive proteomic analysis of JC polyomavirus-infected human astrocytes and their extracellular vesicles.
Journal
Microbiology spectrum
ISSN
2165-0497 (Electronic)
ISSN-L
2165-0497
Publication state
Published
Issued date
12/12/2023
Peer-reviewed
Oui
Volume
11
Number
6
Pages
e0275123
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Progressive multifocal leukoencephalopathy is a crimpling demyelinating disease of the central nervous system caused by JC polyomavirus (JCPyV). Much about JCPyV propagation in the brain remains obscure because of a lack of proper animal models to study the virus in the context of the disease, thus hampering efforts toward the development of new antiviral strategies. Here, having established a robust and representative model of JCPyV infection in human-induced pluripotent stem cell-derived astrocytes, we are able to fully characterize the effect of JCPyV on the biology of the cells and show that the proteomic signature observed for JCPyV-infected astrocytes is extended to extracellular vesicles (EVs). These data suggest that astrocyte-derived EVs found in body fluids might serve as a rich source of information relevant to JCPyV infection in the brain, opening avenues toward better understanding the pathogenesis of the virus and, ultimately, the identification of new antiviral targets.
Keywords
Animals, Humans, JC Virus/physiology, Astrocytes, Proteomics, Polyomavirus Infections, Extracellular Vesicles, Antiviral Agents, JCPyV, PML, astrocytes, extracellular vesicles, hiPSC, model
Pubmed
Web of science
Open Access
Yes
Create date
13/10/2023 9:45
Last modification date
08/08/2024 7:34