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BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population.
Journal of Experimental Medicine
The tumor necrosis factor (TNF) family member B cell activating factor (BAFF) binds B cells and enhances B cell receptor-triggered proliferation. We find that B cell maturation antigen (BCMA), a predicted member of the TNF receptor family expressed primarily in mature B cells, is a receptor for BAFF. Although BCMA was previously localized to the Golgi apparatus, BCMA was found to be expressed on the surface of transfected cells and tonsillar B cells. A soluble form of BCMA, which inhibited the binding of BAFF to a B cell line, induced a dramatic decrease in the number of peripheral B cells when administered in vivo. Moreover, culturing splenic cells in the presence of BAFF increased survival of a percentage of the B cells. These results are consistent with a role for BAFF in maintaining homeostasis of the B cell population.
Animals, B-Cell Activating Factor, B-Cell Maturation Antigen, B-Lymphocytes/immunology, Cell Line, Cell Survival, Homeostasis, Humans, Immunoglobulin G/immunology, Immunoglobulin kappa-Chains/genetics, Immunoglobulin kappa-Chains/immunology, Lymphocyte Activation, Membrane Proteins/genetics, Membrane Proteins/immunology, Mice, Mice, Inbred BALB C, Palatine Tonsil/immunology, Receptors, Tumor Necrosis Factor/genetics, Receptors, Tumor Necrosis Factor/immunology, Recombinant Proteins/immunology, Spleen/immunology, Transfection, Tumor Necrosis Factor-alpha
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