BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population.
Détails
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Etat: Public
Version: de l'auteur⸱e
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_FD7EEF16556C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population.
Périodique
Journal of Experimental Medicine
ISSN
0022-1007 (Print)
ISSN-L
0022-1007
Statut éditorial
Publié
Date de publication
2000
Volume
192
Numéro
1
Pages
129-135
Langue
anglais
Résumé
The tumor necrosis factor (TNF) family member B cell activating factor (BAFF) binds B cells and enhances B cell receptor-triggered proliferation. We find that B cell maturation antigen (BCMA), a predicted member of the TNF receptor family expressed primarily in mature B cells, is a receptor for BAFF. Although BCMA was previously localized to the Golgi apparatus, BCMA was found to be expressed on the surface of transfected cells and tonsillar B cells. A soluble form of BCMA, which inhibited the binding of BAFF to a B cell line, induced a dramatic decrease in the number of peripheral B cells when administered in vivo. Moreover, culturing splenic cells in the presence of BAFF increased survival of a percentage of the B cells. These results are consistent with a role for BAFF in maintaining homeostasis of the B cell population.
Mots-clé
Animals, B-Cell Activating Factor, B-Cell Maturation Antigen, B-Lymphocytes/immunology, Cell Line, Cell Survival, Homeostasis, Humans, Immunoglobulin G/immunology, Immunoglobulin kappa-Chains/genetics, Immunoglobulin kappa-Chains/immunology, Lymphocyte Activation, Membrane Proteins/genetics, Membrane Proteins/immunology, Mice, Mice, Inbred BALB C, Palatine Tonsil/immunology, Receptors, Tumor Necrosis Factor/genetics, Receptors, Tumor Necrosis Factor/immunology, Recombinant Proteins/immunology, Spleen/immunology, Transfection, Tumor Necrosis Factor-alpha
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 16:19
Dernière modification de la notice
20/08/2019 17:28