Article: article from journal or magazin.
Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene.
American journal of human genetics
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients' cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit, is strongly associated with schizophrenia in two case-control studies and in one family study. GCLM gene expression is decreased in patients' fibroblasts. Thus, GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia.
Case-Control Studies, Down-Regulation, Fibroblasts, Gene Frequency, Genetic Predisposition to Disease, Glutamate-Cysteine Ligase, Glutathione, Humans, Oxidative Stress, Polymorphism, Single Nucleotide, RNA, Messenger, Schizophrenia
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