Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene.

Détails

ID Serval
serval:BIB_FC5ABE3EB470
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene.
Périodique
American journal of human genetics
Auteur(s)
Tosic M., Ott J., Barral S., Bovet P., Deppen P., Gheorghita F., Matthey M.L., Parnas J., Preisig M., Saraga M., Solida A., Timm S., Wang A.G., Werge T., Cuénod M., Do K.Q.
ISSN
0002-9297
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
79
Numéro
3
Pages
586-92
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients' cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit, is strongly associated with schizophrenia in two case-control studies and in one family study. GCLM gene expression is decreased in patients' fibroblasts. Thus, GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia.
Mots-clé
Case-Control Studies, Down-Regulation, Fibroblasts, Gene Frequency, Genetic Predisposition to Disease, Glutamate-Cysteine Ligase, Glutathione, Humans, Oxidative Stress, Polymorphism, Single Nucleotide, RNA, Messenger, Schizophrenia
Pubmed
Web of science
Open Access
Oui
Création de la notice
10/03/2008 10:50
Dernière modification de la notice
09/10/2020 21:23
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