Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene.

Details

Serval ID
serval:BIB_FC5ABE3EB470
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene.
Journal
American journal of human genetics
Author(s)
Tosic M., Ott J., Barral S., Bovet P., Deppen P., Gheorghita F., Matthey M.L., Parnas J., Preisig M., Saraga M., Solida A., Timm S., Wang A.G., Werge T., Cuénod M., Do K.Q.
ISSN
0002-9297
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
79
Number
3
Pages
586-92
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients' cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit, is strongly associated with schizophrenia in two case-control studies and in one family study. GCLM gene expression is decreased in patients' fibroblasts. Thus, GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia.
Keywords
Case-Control Studies, Down-Regulation, Fibroblasts, Gene Frequency, Genetic Predisposition to Disease, Glutamate-Cysteine Ligase, Glutathione, Humans, Oxidative Stress, Polymorphism, Single Nucleotide, RNA, Messenger, Schizophrenia
Pubmed
Web of science
Open Access
Yes
Create date
10/03/2008 10:50
Last modification date
20/08/2019 17:27
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