Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum.
Details
State: Public
Version: author
Serval ID
serval:BIB_FAD1260D144C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum.
Journal
Current Opinion in Immunology
ISSN
1879-0372 (Electronic)
ISSN-L
0952-7915
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
23
Number
1
Pages
35-40
Language
english
Abstract
The innate immune system has evolved the capacity to detect specific pathogens and to interrogate cell and tissue integrity in order to mount an appropriate immune response. Loss of homeostasis in the endoplasmic reticulum (ER) triggers the ER-stress response, a hallmark of many inflammatory and infectious diseases. The IRE1/XBP1 branch of the ER-stress signaling pathway has been recently shown to regulate and be regulated by innate immune signaling pathways in both the presence and absence of ER-stress. By contrast, innate immune pathways negatively affect the activation of two other branches of the ER-stress response as evidenced by reduced expression of the pro-apoptotic transcription factor CHOP. Here we will discuss how innate immune pathways and ER-signaling intersect to regulate the intensity and duration of innate immune responses.
Keywords
Animals, Endoplasmic Reticulum/immunology, Endoplasmic Reticulum/metabolism, Humans, Immunity, Innate, Protein Unfolding, Receptors, Immunologic/immunology, Signal Transduction, Stress, Physiological
Pubmed
Web of science
Create date
03/03/2011 13:05
Last modification date
20/08/2019 17:26