Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum.
Détails
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_FAD1260D144C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum.
Périodique
Current Opinion in Immunology
ISSN
1879-0372 (Electronic)
ISSN-L
0952-7915
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
23
Numéro
1
Pages
35-40
Langue
anglais
Résumé
The innate immune system has evolved the capacity to detect specific pathogens and to interrogate cell and tissue integrity in order to mount an appropriate immune response. Loss of homeostasis in the endoplasmic reticulum (ER) triggers the ER-stress response, a hallmark of many inflammatory and infectious diseases. The IRE1/XBP1 branch of the ER-stress signaling pathway has been recently shown to regulate and be regulated by innate immune signaling pathways in both the presence and absence of ER-stress. By contrast, innate immune pathways negatively affect the activation of two other branches of the ER-stress response as evidenced by reduced expression of the pro-apoptotic transcription factor CHOP. Here we will discuss how innate immune pathways and ER-signaling intersect to regulate the intensity and duration of innate immune responses.
Mots-clé
Animals, Endoplasmic Reticulum/immunology, Endoplasmic Reticulum/metabolism, Humans, Immunity, Innate, Protein Unfolding, Receptors, Immunologic/immunology, Signal Transduction, Stress, Physiological
Pubmed
Web of science
Création de la notice
03/03/2011 13:05
Dernière modification de la notice
20/08/2019 17:26