Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Hepatitis C virus infection: in vivo and in vitro models.
Journal of Viral Hepatitis
Publication types: Journal Article ; Review
Major advances in the understanding of the molecular biology of hepatitis C virus (HCV) have been made recently. While the chimpanzee is the only established animal model of HCV infection, several in vivo and in vitro models have been established that allow us to study various aspects of the viral life cycle. In particular, the replicon system and the production of recombinant infectious virions revolutionized the investigation of HCV-RNA replication and rendered all steps of the viral life cycle, including entry and release of viral particles, amenable to systematic analysis. In the following we will review the different in vivo and in vitro models of HCV infection.
Animals, Callitrichinae, Cell Culture Techniques, Disease Models, Animal, Hepacivirus/physiology, Hepatitis B, Humans, Mice, Mice, Transgenic, Pan troglodytes
Web of science
Last modification date