Hepatitis C virus infection: in vivo and in vitro models.

Détails

ID Serval
serval:BIB_F9B149C0DC53
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Hepatitis C virus infection: in vivo and in vitro models.
Périodique
Journal of Viral Hepatitis
Auteur⸱e⸱s
Brass V., Moradpour D., Blum H.E.
ISSN
1352-0504
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
14
Numéro
Suppl. 1
Pages
64-67
Langue
anglais
Notes
Publication types: Journal Article ; Review
Résumé
Major advances in the understanding of the molecular biology of hepatitis C virus (HCV) have been made recently. While the chimpanzee is the only established animal model of HCV infection, several in vivo and in vitro models have been established that allow us to study various aspects of the viral life cycle. In particular, the replicon system and the production of recombinant infectious virions revolutionized the investigation of HCV-RNA replication and rendered all steps of the viral life cycle, including entry and release of viral particles, amenable to systematic analysis. In the following we will review the different in vivo and in vitro models of HCV infection.
Mots-clé
Animals, Callitrichinae, Cell Culture Techniques, Disease Models, Animal, Hepacivirus/physiology, Hepatitis B, Humans, Mice, Mice, Transgenic, Pan troglodytes
Pubmed
Web of science
Création de la notice
11/09/2009 8:32
Dernière modification de la notice
20/08/2019 16:25
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