Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

Willer, C.J.; Speliotes, E.K.; Loos, R.J.; Li, S.; Lindgren, C.M.; Heid, I.M.; Berndt, S.I.; Elliott, A.L.; Jackson, A.U.; Lamina, C.; Lettre, G.; Lim, N.; Lyon, H.N.; McCarroll, S.A.; Papadakis, K.; Qi, L.; Randall, J.C.; Roccasecca, R.M.; Sanna, S.; Scheet, P.; Weedon, M.N.; Wheeler, E.; Zhao, J.H.; Jacobs, L.C.; Prokopenko, I.; Soranzo, N.; Tanaka, T.; Timpson, N.J.; Almgren, P.; Bennett, A.; Bergman, R.N.; Bingham, S.A.; Bonnycastle, L.L.; Brown, M.; Burtt, N.P.; Chines, P.; Coin, L.; Collins, F.S.; Connell, J.M.; Cooper, C.; Smith, G.D.; Dennison, E.M.; Deodhar, P.; Elliott, P.; Erdos, M.R.; Estrada, K.; Evans, D.M.; Gianniny, L.; Gieger, C.; Gillson, C.J.; Guiducci, C.; Hackett, R.; Hadley, D.; Hall, A.S.; Havulinna, A.S.; Hebebrand, J.; Hofman, A.; Isomaa, B.; Jacobs, K.B.; Johnson, T.; Jousilahti, P.; Jovanovic, Z.; Khaw, K.T.; Kraft, P.; Kuokkanen, M.; Kuusisto, J.; Laitinen, J.; Lakatta, E.G.; Luan, J.; Luben, R.N.; Mangino, M.; McArdle, W.L.; Meitinger, T.; Mulas, A.; Munroe, P.B.; Narisu, N.; Ness, A.R.; Northstone, K.; O'Rahilly, S.; Purmann, C.; Rees, M.G.; Ridderstråle, M.; Ring, S.M.; Rivadeneira, F.; Ruokonen, A.; Sandhu, M.S.; Saramies, J.; Scott, L.J.; Scuteri, A.; Silander, K.; Sims, M.A.; Song, K.; Stephens, J.; Stevens, S.; Stringham, H.M.; Tung, Y.C.; Valle, T.T.; Van Duijn, C.M.; Vimaleswaran, K.S.; Vollenweider, P.; Waeber, G.; Wallace, C.; Watanabe, R.M.; Waterworth, D.M.; Watkins, N.; Witteman, J.C.; Witteman, J.C.; Zeggini, E.; Zhai, G.; Zillikens, M.C.; Altshuler, D.; Caulfield, M.J.; Chanock, S.J.; Farooqi, I.S.; Ferrucci, L.; Guralnik, J.M.; Hattersley, A.T.; Hu, F.B.; Jarvelin, M.R.; Laakso, M.; Mooser, V.; Ong, K.K.; Ouwehand, W.H.; Salomaa, V.; Samani, N.J.; Spector, T.D.; Tuomi, T.; Tuomilehto, J.; Uda, M.; Uitterlinden, A.G.; Wareham, N.J.; Deloukas, P.; Frayling, T.M.; Groop, L.C.; Hayes, R.B.; Hunter, D.J.; Mohlke, K.L.; Peltonen, L.; Schlessinger, D.; Strachan, D.P.; Wichmann, H.E.; McCarthy, M.I.; Boehnke, M.; Barroso, I.; Abecasis, G.R.; Hirschhorn, J.N.

doi:10.1038/ng.287

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

Details

Download: 5_19079261_Postprint.pdf (1905.94 [Ko])
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Version: Author's accepted manuscript

Serval ID

serval:BIB_F8992FC64167

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

Journal

Nature Genetics

Author(s)

Willer C.J., Speliotes E.K., Loos R.J., Li S., Lindgren C.M., Heid I.M., Berndt S.I., Elliott A.L., Jackson A.U., Lamina C., Lettre G., Lim N., Lyon H.N., McCarroll S.A., Papadakis K., Qi L., Randall J.C., Roccasecca R.M., Sanna S., Scheet P., Weedon M.N., Wheeler E., Zhao J.H., Jacobs L.C., Prokopenko I., Soranzo N., Tanaka T., Timpson N.J., Almgren P., Bennett A., Bergman R.N., Bingham S.A., Bonnycastle L.L., Brown M., Burtt N.P., Chines P., Coin L., Collins F.S., Connell J.M., Cooper C., Smith G.D., Dennison E.M., Deodhar P., Elliott P., Erdos M.R., Estrada K., Evans D.M., Gianniny L., Gieger C., Gillson C.J., Guiducci C., Hackett R., Hadley D., Hall A.S., Havulinna A.S., Hebebrand J., Hofman A., Isomaa B., Jacobs K.B., Johnson T., Jousilahti P., Jovanovic Z., Khaw K.T., Kraft P., Kuokkanen M., Kuusisto J., Laitinen J., Lakatta E.G., Luan J., Luben R.N., Mangino M., McArdle W.L., Meitinger T., Mulas A., Munroe P.B., Narisu N., Ness A.R., Northstone K., O'Rahilly S., Purmann C., Rees M.G., Ridderstråle M., Ring S.M., Rivadeneira F., Ruokonen A., Sandhu M.S., Saramies J., Scott L.J., Scuteri A., Silander K., Sims M.A., Song K., Stephens J., Stevens S., Stringham H.M., Tung Y.C., Valle T.T., Van Duijn C.M., Vimaleswaran K.S., Vollenweider P., Waeber G., Wallace C., Watanabe R.M., Waterworth D.M., Watkins N., Witteman J.C., Witteman J.C., Zeggini E., Zhai G., Zillikens M.C., Altshuler D., Caulfield M.J., Chanock S.J., Farooqi I.S., Ferrucci L., Guralnik J.M., Hattersley A.T., Hu F.B., Jarvelin M.R., Laakso M., Mooser V., Ong K.K., Ouwehand W.H., Salomaa V., Samani N.J., Spector T.D., Tuomi T., Tuomilehto J., Uda M., Uitterlinden A.G., Wareham N.J., Deloukas P., Frayling T.M., Groop L.C., Hayes R.B., Hunter D.J., Mohlke K.L., Peltonen L., Schlessinger D., Strachan D.P., Wichmann H.E., McCarthy M.I., Boehnke M., Barroso I., Abecasis G.R., Hirschhorn J.N.

ISSN

1546-1718

Publication state

Published

Issued date

2009

Peer-reviewed

Oui

Volume

Number

Pages

25-34

Language

english

Abstract

Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.

Keywords

Alleles, Anthropometry, Body Mass Index, Body Weight, Central Nervous System, Cohort Studies, Gene Dosage, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Meta-Analysis as Topic, Obesity, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Quantitative Trait, Heritable, Colaus Study

URN

urn:nbn:ch:serval-BIB_F8992FC641673

OAI-PMH

oai:serval.unil.ch:BIB_F8992FC64167

DOI

10.1038/ng.287

Pubmed

19079261

Web of science

000262085300013

Open Access

Yes