Interaction between mianserin and acenocoumarin: a single case study.

Details

Serval ID
serval:BIB_F5C2D3C0E576
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Interaction between mianserin and acenocoumarin: a single case study.
Journal
International journal of clinical pharmacology and therapeutics
Author(s)
Baettig D., Tillement J.P., Baumann P.
ISSN
0946-1965 (Print)
ISSN-L
0946-1965
Publication state
Published
Issued date
04/1994
Peer-reviewed
Oui
Volume
32
Number
4
Pages
165-167
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Abstract
A 62-year-old male patient, suffering from a hypertensive cardiopathy, an arteriopathy of the lower extremities and a type II insulin independent diabetes had a prothrombin time ratio R of 2.15 (therapeutic range: 2.1-1.45) during a daily treatment of 4-6 mg acenocoumarin. On admission to the psychiatric hospital for depression, a mianserin treatment was commenced, leading to a sharp modification in the PT ratio R, in effect that the acenocoumarin treatment had to be increased to keep R within the therapeutic range. The possible mechanism of this interaction between mianserin and acenocoumarin is discussed, taking into account the possible role of the comedicated amiodarone.
Keywords
Acenocoumarol/therapeutic use, Amiodarone/pharmacology, Blood Coagulation Disorders/complications, Blood Coagulation Disorders/drug therapy, Depressive Disorder/complications, Depressive Disorder/drug therapy, Drug Interactions, Humans, Male, Mianserin/therapeutic use, Middle Aged, Prothrombin Time
Pubmed
Web of science
Create date
12/01/2021 17:16
Last modification date
15/04/2023 6:51
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