Interaction between mianserin and acenocoumarin: a single case study.

Détails

ID Serval
serval:BIB_F5C2D3C0E576
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Interaction between mianserin and acenocoumarin: a single case study.
Périodique
International journal of clinical pharmacology and therapeutics
Auteur⸱e⸱s
Baettig D., Tillement J.P., Baumann P.
ISSN
0946-1965 (Print)
ISSN-L
0946-1965
Statut éditorial
Publié
Date de publication
04/1994
Peer-reviewed
Oui
Volume
32
Numéro
4
Pages
165-167
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Résumé
A 62-year-old male patient, suffering from a hypertensive cardiopathy, an arteriopathy of the lower extremities and a type II insulin independent diabetes had a prothrombin time ratio R of 2.15 (therapeutic range: 2.1-1.45) during a daily treatment of 4-6 mg acenocoumarin. On admission to the psychiatric hospital for depression, a mianserin treatment was commenced, leading to a sharp modification in the PT ratio R, in effect that the acenocoumarin treatment had to be increased to keep R within the therapeutic range. The possible mechanism of this interaction between mianserin and acenocoumarin is discussed, taking into account the possible role of the comedicated amiodarone.
Mots-clé
Acenocoumarol/therapeutic use, Amiodarone/pharmacology, Blood Coagulation Disorders/complications, Blood Coagulation Disorders/drug therapy, Depressive Disorder/complications, Depressive Disorder/drug therapy, Drug Interactions, Humans, Male, Mianserin/therapeutic use, Middle Aged, Prothrombin Time
Pubmed
Web of science
Création de la notice
12/01/2021 16:16
Dernière modification de la notice
15/04/2023 5:51
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