Targeting autophagy to prevent neonatal stroke damage.
Details
Serval ID
serval:BIB_F59251CD23FD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Targeting autophagy to prevent neonatal stroke damage.
Journal
Autophagy
ISSN
1554-8635[electronic], 1554-8627[linking]
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
5
Number
7
Pages
1060-1061
Language
english
Notes
Publication types: Journal Article
Abstract
Cell death due to cerebral ischemia has been attributed to necrosis and apoptosis, but autophagic mechanisms have recently been implicated as well. Using rats exposed to neonatal focal cerebral ischemia, we have shown that lysosomal and autophagic activities are increased in ischemic neurons, and have obtained strong neuroprotection by post-ischemic inhibition of autophagy.
Keywords
Animals, Animals, Newborn, Autophagy/physiology, Brain Ischemia/pathology, Brain Ischemia/physiopathology, Cell Death/physiology, Lysosomes/metabolism, Neurons/metabolism, Rats
Pubmed
Web of science
Create date
15/09/2009 8:57
Last modification date
20/08/2019 17:22
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