Article: article from journal or magazin.
Targeting autophagy to prevent neonatal stroke damage.
Publication types: Journal Article
Cell death due to cerebral ischemia has been attributed to necrosis and apoptosis, but autophagic mechanisms have recently been implicated as well. Using rats exposed to neonatal focal cerebral ischemia, we have shown that lysosomal and autophagic activities are increased in ischemic neurons, and have obtained strong neuroprotection by post-ischemic inhibition of autophagy.
Animals, Animals, Newborn, Autophagy/physiology, Brain Ischemia/pathology, Brain Ischemia/physiopathology, Cell Death/physiology, Lysosomes/metabolism, Neurons/metabolism, Rats
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