Targeting autophagy to prevent neonatal stroke damage.
Détails
ID Serval
serval:BIB_F59251CD23FD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Targeting autophagy to prevent neonatal stroke damage.
Périodique
Autophagy
ISSN
1554-8635[electronic], 1554-8627[linking]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
5
Numéro
7
Pages
1060-1061
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Cell death due to cerebral ischemia has been attributed to necrosis and apoptosis, but autophagic mechanisms have recently been implicated as well. Using rats exposed to neonatal focal cerebral ischemia, we have shown that lysosomal and autophagic activities are increased in ischemic neurons, and have obtained strong neuroprotection by post-ischemic inhibition of autophagy.
Mots-clé
Animals, Animals, Newborn, Autophagy/physiology, Brain Ischemia/pathology, Brain Ischemia/physiopathology, Cell Death/physiology, Lysosomes/metabolism, Neurons/metabolism, Rats
Pubmed
Web of science
Création de la notice
15/09/2009 8:57
Dernière modification de la notice
20/08/2019 17:22
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