Firing Up Cold Tumors.

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Serval ID
serval:BIB_F50ED56DE9EB
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
UNIL/CHUV
Title
Firing Up Cold Tumors.
Journal
Trends in cancer
Author(s)
Cheng W.C., Ho P.C.
ISSN
2405-8025 (Electronic)
ISSN-L
2405-8025
Publication state
Published
Issued date
09/2019
Peer-reviewed
Oui
Volume
5
Number
9
Pages
528-530
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Elucidating how tumor-intrinsic pathways regulate T cell infiltration in tumors is crucial for developing new therapeutic strategies for immune checkpoint blockade therapy. Here, we review recent progress on how these pathways orchestrate immune status in tumors and discuss the potential interventions for reprogramming the tumor microenvironment for cancer treatment.
Keywords
Antineoplastic Agents, Immunological/pharmacology, Antineoplastic Agents, Immunological/therapeutic use, B7-H1 Antigen/antagonists & inhibitors, B7-H1 Antigen/immunology, B7-H1 Antigen/metabolism, Drug Resistance, Neoplasm/drug effects, Drug Resistance, Neoplasm/genetics, Humans, Lymphocytes, Tumor-Infiltrating/drug effects, Lymphocytes, Tumor-Infiltrating/immunology, Lymphocytes, Tumor-Infiltrating/metabolism, Mutation, Neoplasms/drug therapy, Neoplasms/genetics, Neoplasms/immunology, Neoplasms/pathology, Programmed Cell Death 1 Receptor/antagonists & inhibitors, Programmed Cell Death 1 Receptor/immunology, Programmed Cell Death 1 Receptor/metabolism, T-Lymphocytes/drug effects, T-Lymphocytes/immunology, T-Lymphocytes/metabolism, Tumor Escape/drug effects, Tumor Escape/genetics, Tumor Microenvironment/drug effects, Tumor Microenvironment/genetics, Tumor Microenvironment/immunology, Uncoupling Protein 2/metabolism, antitumor immune cycle, conventional type I dendritic cells, immune checkpoint blockade, resistance, tumor microenvironment
OAI-PMH
oai:serval.unil.ch:BIB_F50ED56DE9EB
DOI
10.1016/j.trecan.2019.06.005
Pubmed
31474357
Web of science
000484346500003
Create date
13/09/2019 18:54
Last modification date
05/09/2020 6:26
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