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Intraoperative redosing of cefazolin and risk for surgical site infection in cardiac surgery
Emerging Infectious Diseases
Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. --- Old month value: Sep-Oct
Intraoperative redosing of prophylactic antibiotics is recommended for prolonged surgical procedures, although its efficacy has not been assessed. We retrospectively compared the risk of surgical site infections in 1,548 patients who underwent cardiac surgery lasting >240 min after preoperative administration of cefazolin prophylaxis. The overall risk of surgical site infection was similar among patients with (43 [9.4%] of 459) and without (101 [9.3%] of 1,089) intraoperative redosing (odds ratio [OR] 1.01, 95% confidence interval [CI] 0.70-1.47). However, redosing was beneficial in procedures lasting >400 min: infection occurred in 14 (7.7%) of 182 patients with redosing and in 32 (16.0%) of 200 patients without (adjusted OR 0.44, 95% CI 0.23-0.86). Intraoperative redosing of cefazolin was associated with a 16% reduction in the overall risk for surgical site infection after cardiac surgery, including procedures lasting <240 min.
Adolescent Adult Aged Aged, 80 and over *Antibiotic Prophylaxis Cardiac Surgical Procedures/*adverse effects Cefazolin/administration & dosage/*therapeutic use Cephalosporins/administration & dosage/*therapeutic use Drug Administration Schedule Female Humans *Intraoperative Care Male Middle Aged Retrospective Studies Risk Factors Surgical Wound Infection/*prevention & control Time Factors
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