Intraoperative redosing of cefazolin and risk for surgical site infection in cardiac surgery

Détails

ID Serval
serval:BIB_F3CA9FD606C3
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Vulgarisation: article de la presse quotidienne ou article de vulgarisation scientifique.
Collection
Publications
Institution
Titre
Intraoperative redosing of cefazolin and risk for surgical site infection in cardiac surgery
Périodique
Emerging Infectious Diseases
Auteur(s)
Zanetti  G., Giardina  R., Platt  R.
ISSN
1080-6040
Statut éditorial
Publié
Date de publication
10/2001
Peer-reviewed
Oui
Volume
7
Numéro
5
Pages
828-31
Notes
Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. --- Old month value: Sep-Oct
Résumé
Intraoperative redosing of prophylactic antibiotics is recommended for prolonged surgical procedures, although its efficacy has not been assessed. We retrospectively compared the risk of surgical site infections in 1,548 patients who underwent cardiac surgery lasting >240 min after preoperative administration of cefazolin prophylaxis. The overall risk of surgical site infection was similar among patients with (43 [9.4%] of 459) and without (101 [9.3%] of 1,089) intraoperative redosing (odds ratio [OR] 1.01, 95% confidence interval [CI] 0.70-1.47). However, redosing was beneficial in procedures lasting >400 min: infection occurred in 14 (7.7%) of 182 patients with redosing and in 32 (16.0%) of 200 patients without (adjusted OR 0.44, 95% CI 0.23-0.86). Intraoperative redosing of cefazolin was associated with a 16% reduction in the overall risk for surgical site infection after cardiac surgery, including procedures lasting <240 min.
Mots-clé
Adolescent Adult Aged Aged, 80 and over *Antibiotic Prophylaxis Cardiac Surgical Procedures/*adverse effects Cefazolin/administration & dosage/*therapeutic use Cephalosporins/administration & dosage/*therapeutic use Drug Administration Schedule Female Humans *Intraoperative Care Male Middle Aged Retrospective Studies Risk Factors Surgical Wound Infection/*prevention & control Time Factors
Pubmed
Web of science
Création de la notice
21/01/2008 10:04
Dernière modification de la notice
20/08/2019 16:20
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