Intraoperative redosing of cefazolin and risk for surgical site infection in cardiac surgery

Details

Serval ID
serval:BIB_F3CA9FD606C3
Type
Article: article from journal or magazin.
Publication sub-type
Vulgarization: article from the non-specific scientific community or a vulgarization of a scientifical paper.
Collection
Publications
Institution
Title
Intraoperative redosing of cefazolin and risk for surgical site infection in cardiac surgery
Journal
Emerging Infectious Diseases
Author(s)
Zanetti  G., Giardina  R., Platt  R.
ISSN
1080-6040
Publication state
Published
Issued date
10/2001
Peer-reviewed
Oui
Volume
7
Number
5
Pages
828-31
Notes
Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. --- Old month value: Sep-Oct
Abstract
Intraoperative redosing of prophylactic antibiotics is recommended for prolonged surgical procedures, although its efficacy has not been assessed. We retrospectively compared the risk of surgical site infections in 1,548 patients who underwent cardiac surgery lasting >240 min after preoperative administration of cefazolin prophylaxis. The overall risk of surgical site infection was similar among patients with (43 [9.4%] of 459) and without (101 [9.3%] of 1,089) intraoperative redosing (odds ratio [OR] 1.01, 95% confidence interval [CI] 0.70-1.47). However, redosing was beneficial in procedures lasting >400 min: infection occurred in 14 (7.7%) of 182 patients with redosing and in 32 (16.0%) of 200 patients without (adjusted OR 0.44, 95% CI 0.23-0.86). Intraoperative redosing of cefazolin was associated with a 16% reduction in the overall risk for surgical site infection after cardiac surgery, including procedures lasting <240 min.
Keywords
Adolescent Adult Aged Aged, 80 and over *Antibiotic Prophylaxis Cardiac Surgical Procedures/*adverse effects Cefazolin/administration & dosage/*therapeutic use Cephalosporins/administration & dosage/*therapeutic use Drug Administration Schedule Female Humans *Intraoperative Care Male Middle Aged Retrospective Studies Risk Factors Surgical Wound Infection/*prevention & control Time Factors
Pubmed
Web of science
Create date
21/01/2008 11:04
Last modification date
20/08/2019 17:20
Usage data