Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Clinical and neuroimaging features of familial Alzheimer's disease.
Annals of the New York Academy of Sciences
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Subtle phenotypic differences between familial Alzheimer's disease (FAD) pedigrees can be identified which may reflect the genetic and allelic heterogeneity of the disease. Positron emission tomography (PET) of APP mutation and chromosome 14-linked FAD pedigree members reveals biparietal bitemporal hypometabolism. Scanning of asymptomatic at-risk individuals reveals a similar, but quantitatively less severe, pattern of hypometabolism.
Alzheimer Disease/genetics, Alzheimer Disease/metabolism, Amyloid beta-Protein Precursor/genetics, Brain/metabolism, Chromosomes, Human, Pair 14, Humans, Mental Health, Pedigree, Risk Factors, Tomography, Emission-Computed
Web of science
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