Clinical and neuroimaging features of familial Alzheimer's disease.
Détails
ID Serval
serval:BIB_F3B275E213CC
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Clinical and neuroimaging features of familial Alzheimer's disease.
Périodique
Annals of the New York Academy of Sciences
ISSN
0077-8923 (Print)
ISSN-L
0077-8923
Statut éditorial
Publié
Date de publication
1996
Volume
777
Pages
49-56
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Résumé
Subtle phenotypic differences between familial Alzheimer's disease (FAD) pedigrees can be identified which may reflect the genetic and allelic heterogeneity of the disease. Positron emission tomography (PET) of APP mutation and chromosome 14-linked FAD pedigree members reveals biparietal bitemporal hypometabolism. Scanning of asymptomatic at-risk individuals reveals a similar, but quantitatively less severe, pattern of hypometabolism.
Mots-clé
Alzheimer Disease/genetics, Alzheimer Disease/metabolism, Amyloid beta-Protein Precursor/genetics, Brain/metabolism, Chromosomes, Human, Pair 14, Humans, Mental Health, Pedigree, Risk Factors, Tomography, Emission-Computed
Pubmed
Web of science
Création de la notice
16/09/2011 20:19
Dernière modification de la notice
20/08/2019 17:20
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