Clinical and neuroimaging features of familial Alzheimer's disease.
Details
Serval ID
serval:BIB_F3B275E213CC
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Clinical and neuroimaging features of familial Alzheimer's disease.
Journal
Annals of the New York Academy of Sciences
ISSN
0077-8923 (Print)
ISSN-L
0077-8923
Publication state
Published
Issued date
1996
Volume
777
Pages
49-56
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Abstract
Subtle phenotypic differences between familial Alzheimer's disease (FAD) pedigrees can be identified which may reflect the genetic and allelic heterogeneity of the disease. Positron emission tomography (PET) of APP mutation and chromosome 14-linked FAD pedigree members reveals biparietal bitemporal hypometabolism. Scanning of asymptomatic at-risk individuals reveals a similar, but quantitatively less severe, pattern of hypometabolism.
Keywords
Alzheimer Disease/genetics, Alzheimer Disease/metabolism, Amyloid beta-Protein Precursor/genetics, Brain/metabolism, Chromosomes, Human, Pair 14, Humans, Mental Health, Pedigree, Risk Factors, Tomography, Emission-Computed
Pubmed
Web of science
Create date
16/09/2011 19:19
Last modification date
20/08/2019 16:20
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