Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Adipogenesis: a cross-talk between cell proliferation and cell differentiation.
Annals of Medicine
The transition between cell proliferation and cell differentiation taking place during adipocyte differentiation is a tightly regulated process where both cell cycle regulators and differentiating factors interact, creating a cascade of events leading to the commitment of the cells into the adipocyte phenotype. Based on in-vitro cell models of adipocyte differentiation, the different stages of adipogenesis have been established, each of them with a particular pattern of gene expression. Re-entry into the cell cycle of growth-arrested preadipocytes is known as the clonal expansion phase. Growth-arrested preadipocytes undergo several rounds of cell cycle before terminally differentiating into adipocytes, suggesting that a cross-talk might exist between the cell cycle or the cell proliferation machinery and the factors controlling cell differentiation. I will focus this review on the influence of the proliferative phase of preadipocytes in the adipocyte differentiation process.
Adipocytes/cytology, Adipocytes/physiology, Cell Cycle/physiology, Cell Differentiation/physiology, Cell Division/physiology, Genes, myc/physiology, Humans, Receptor Cross-Talk/physiology, Signal Transduction/physiology, Transcription Factors/physiology
Web of science
Last modification date