Adipogenesis: a cross-talk between cell proliferation and cell differentiation.

Détails

ID Serval
serval:BIB_F318893025E0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Adipogenesis: a cross-talk between cell proliferation and cell differentiation.
Périodique
Annals of Medicine
Auteur(s)
Fajas L.
ISSN
0785-3890 (Print)
ISSN-L
0785-3890
Statut éditorial
Publié
Date de publication
2003
Volume
35
Numéro
2
Pages
79-85
Langue
anglais
Résumé
The transition between cell proliferation and cell differentiation taking place during adipocyte differentiation is a tightly regulated process where both cell cycle regulators and differentiating factors interact, creating a cascade of events leading to the commitment of the cells into the adipocyte phenotype. Based on in-vitro cell models of adipocyte differentiation, the different stages of adipogenesis have been established, each of them with a particular pattern of gene expression. Re-entry into the cell cycle of growth-arrested preadipocytes is known as the clonal expansion phase. Growth-arrested preadipocytes undergo several rounds of cell cycle before terminally differentiating into adipocytes, suggesting that a cross-talk might exist between the cell cycle or the cell proliferation machinery and the factors controlling cell differentiation. I will focus this review on the influence of the proliferative phase of preadipocytes in the adipocyte differentiation process.
Mots-clé
Adipocytes/cytology, Adipocytes/physiology, Cell Cycle/physiology, Cell Differentiation/physiology, Cell Division/physiology, Genes, myc/physiology, Humans, Receptor Cross-Talk/physiology, Signal Transduction/physiology, Transcription Factors/physiology
Pubmed
Web of science
Création de la notice
07/03/2013 16:05
Dernière modification de la notice
20/08/2019 16:20
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