AKAP signaling complexes at the cytoskeleton

Détails

ID Serval
serval:BIB_F1934F8E1DAF
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
AKAP signaling complexes at the cytoskeleton
Périodique
Journal of Cell Science
Auteur(s)
Diviani  D., Scott  J. D.
ISSN
0021-9533 (Print)
Statut éditorial
Publié
Date de publication
04/2001
Volume
114
Numéro
Pt 8
Pages
1431-7
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S.
Review --- Old month value: Apr
Résumé
Targeting of protein kinases and phosphatases to the cytoskeleton enhances the regulation of signal transduction events. The assembly of cytoskeletal signaling complexes facilitates the relay of messages from membrane receptors to specific sites on the actin cytoskeleton. These signals influence fundamental cell properties, such as shape, movement and division. Targeting of the cAMP-dependent kinase (PKA) to the cytoskeleton is achieved through interaction with A-kinase anchoring proteins (AKAPs). AKAPs maintain multivalent signaling complexes by binding additional enzymes, including kinases and phosphatases.
Mots-clé
Actins/chemistry/metabolism *Adaptor Proteins, Signal Transducing Animals Antigens/chemistry/metabolism Carrier Proteins/chemistry/*metabolism Centrosome/*metabolism/ultrastructure Cyclic AMP-Dependent Protein Kinases/chemistry/*metabolism *Cytoskeletal Proteins Cytoskeleton/*metabolism/ultrastructure Humans Membrane Proteins/chemistry/metabolism Microtubule-Associated Proteins/chemistry/metabolism Microtubules/chemistry/*metabolism/ultrastructure Proteins/genetics/metabolism Signal Transduction/physiology Wiskott-Aldrich Syndrome Protein
Pubmed
Web of science
Création de la notice
24/01/2008 13:14
Dernière modification de la notice
03/03/2018 22:38
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