Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine

Détails

ID Serval
serval:BIB_F1121730FC01
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine
Périodique
Antimicrobial Agents and Chemotherapy
Auteur(s)
Osborne  C. S., Leitner  I., Hofbauer  B., Fielding  C. A., Favre  B., Ryder  N. S.
ISSN
0066-4804 (Print)
Statut éditorial
Publié
Date de publication
06/2006
Volume
50
Numéro
6
Pages
2234-6
Notes
Comparative Study
Journal Article --- Old month value: Jun
Résumé
We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L.
Mots-clé
Amino Acid Substitution Antifungal Agents/*pharmacology Base Sequence Cloning, Molecular Colony Count, Microbial Drug Resistance, Fungal/*genetics Ergosterol/biosynthesis Humans Microbial Sensitivity Tests Molecular Sequence Data Naphthalenes/*pharmacology Sequence Analysis, DNA Squalene Monooxygenase/chemistry/metabolism Trichophyton/*drug effects/isolation & purification/*metabolism
Pubmed
Web of science
Création de la notice
25/01/2008 17:32
Dernière modification de la notice
03/03/2018 22:37
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