Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine
Détails
ID Serval
serval:BIB_F1121730FC01
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine
Périodique
Antimicrobial Agents and Chemotherapy
ISSN
0066-4804 (Print)
Statut éditorial
Publié
Date de publication
06/2006
Volume
50
Numéro
6
Pages
2234-6
Notes
Comparative Study
Journal Article --- Old month value: Jun
Journal Article --- Old month value: Jun
Résumé
We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L.
Mots-clé
Amino Acid Substitution
Antifungal Agents/*pharmacology
Base Sequence
Cloning, Molecular
Colony Count, Microbial
Drug Resistance, Fungal/*genetics
Ergosterol/biosynthesis
Humans
Microbial Sensitivity Tests
Molecular Sequence Data
Naphthalenes/*pharmacology
Sequence Analysis, DNA
Squalene Monooxygenase/chemistry/metabolism
Trichophyton/*drug effects/isolation & purification/*metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 16:32
Dernière modification de la notice
20/08/2019 16:18
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