Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine

Osborne,  C. S.; Leitner,  I.; Hofbauer,  B.; Fielding,  C. A.; Favre,  B.; Ryder,  N. S.

doi:10.1128/AAC.01600-05

Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine

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Serval ID

serval:BIB_F1121730FC01

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine

Journal

Antimicrobial Agents and Chemotherapy

Author(s)

Osborne C. S., Leitner I., Hofbauer B., Fielding C. A., Favre B., Ryder N. S.

ISSN

0066-4804 (Print)

Publication state

Published

Issued date

06/2006

Volume

Number

Pages

2234-6

Notes

Comparative Study
Journal Article --- Old month value: Jun

Abstract

We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L.

Keywords

Amino Acid Substitution Antifungal Agents/*pharmacology Base Sequence Cloning, Molecular Colony Count, Microbial Drug Resistance, Fungal/*genetics Ergosterol/biosynthesis Humans Microbial Sensitivity Tests Molecular Sequence Data Naphthalenes/*pharmacology Sequence Analysis, DNA Squalene Monooxygenase/chemistry/metabolism Trichophyton/*drug effects/isolation & purification/*metabolism

OAI-PMH

oai:serval.unil.ch:BIB_F1121730FC01

DOI

10.1128/AAC.01600-05

Pubmed

16723593

Web of science

000237932200049

Open Access

Yes

Create date

25/01/2008 17:32