Perforin is present only in normal activated Lyt2+ T lymphocytes and not in L3T4+ cells, but the serine protease granzyme A is made by both subsets
Details
Serval ID
serval:BIB_ECF81A614392
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Perforin is present only in normal activated Lyt2+ T lymphocytes and not in L3T4+ cells, but the serine protease granzyme A is made by both subsets
Journal
EMBO Journal
ISSN
0261-4189 (Print)
Publication state
Published
Issued date
04/1987
Volume
6
Number
4
Pages
933-938
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Apr
Abstract
We show that among the subsets of peripheral T lymphocytes (Lyt2+ L3T4- and L3T4+ Lyt2- cells) activated in short-term cultures by stimulation with H-2 incompatible leukocytes 97% of the cytolytic activity and all detectable perforin activity resides in the Lyt2+ cells. But both populations contain approximately equal amounts of a serine protease, granzyme A, the expression of which was previously thought to be restricted to cytolytic T lymphocytes.
Keywords
Animals Antigens, Ly/*analysis Cells, Cultured Cytoplasmic Granules/enzymology/ultrastructure Cytotoxicity, Immunologic Endopeptidases/*metabolism Granzymes Hemolysis *Lymphocyte Activation Mice Mice, Inbred C57BL Mice, Inbred DBA *Serine Endopeptidases T-Lymphocytes/classification/enzymology/*immunology
Pubmed
Web of science
Create date
24/01/2008 15:18
Last modification date
20/08/2019 16:14
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