Perforin is present only in normal activated Lyt2+ T lymphocytes and not in L3T4+ cells, but the serine protease granzyme A is made by both subsets
Détails
ID Serval
serval:BIB_ECF81A614392
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Perforin is present only in normal activated Lyt2+ T lymphocytes and not in L3T4+ cells, but the serine protease granzyme A is made by both subsets
Périodique
EMBO Journal
ISSN
0261-4189 (Print)
Statut éditorial
Publié
Date de publication
04/1987
Volume
6
Numéro
4
Pages
933-938
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Apr
Résumé
We show that among the subsets of peripheral T lymphocytes (Lyt2+ L3T4- and L3T4+ Lyt2- cells) activated in short-term cultures by stimulation with H-2 incompatible leukocytes 97% of the cytolytic activity and all detectable perforin activity resides in the Lyt2+ cells. But both populations contain approximately equal amounts of a serine protease, granzyme A, the expression of which was previously thought to be restricted to cytolytic T lymphocytes.
Mots-clé
Animals Antigens, Ly/*analysis Cells, Cultured Cytoplasmic Granules/enzymology/ultrastructure Cytotoxicity, Immunologic Endopeptidases/*metabolism Granzymes Hemolysis *Lymphocyte Activation Mice Mice, Inbred C57BL Mice, Inbred DBA *Serine Endopeptidases T-Lymphocytes/classification/enzymology/*immunology
Pubmed
Web of science
Création de la notice
24/01/2008 16:18
Dernière modification de la notice
20/08/2019 17:14
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