Article: article from journal or magazin.
Return of esophageal peristalsis after nifedipine therapy in patients with idiopathic esophageal achalasia
American Journal of Gastroenterology
Journal Article --- Old month value: Dec
This study was carried out to demonstrate the possible return of esophageal peristalsis in patients affected by esophageal achalasia chronically treated with sublingual nifedipine and to investigate which parameters are correlated with the return of peristalsis. Thirty-two patients were treated with sublingual nifedipine 10-20 mg taken 30 min before meals. A clinical and manometric evaluation was performed before and after 6 months of therapy. Before treatment, in no patient was peristaltic activity recorded. After 6 months, peristalsis was observed in six patients. In this group, no pretreatment manometric parameter was different from that of the remaining achalasic patients; only the clinical history of dysphagia was significantly shorter (p < 0.001) and the esophageal diameter significantly less (p < 0.001). In conclusion, chronic treatment with sublingual nifedipine can induce a return of esophageal peristalsis in patients with a short clinical history of disease and slightly dilated esophagus.
Administration, Sublingual Adolescent Adult Aged Aged, 80 and over Deglutition/physiology Esophageal Achalasia/*drug therapy/physiopathology Esophagus/*physiopathology Female Humans Male Manometry Middle Aged Muscle Tonus/drug effects/physiology Nifedipine/*therapeutic use Peristalsis/drug effects/physiology
Web of science
Last modification date