Return of esophageal peristalsis after nifedipine therapy in patients with idiopathic esophageal achalasia

Détails

ID Serval
serval:BIB_E89CB8160B1B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Return of esophageal peristalsis after nifedipine therapy in patients with idiopathic esophageal achalasia
Périodique
American Journal of Gastroenterology
Auteur(s)
Coccia  G., Bortolotti  M., Michetti  P., Dodero  M.
ISSN
0002-9270 (Print)
Statut éditorial
Publié
Date de publication
12/1992
Volume
87
Numéro
12
Pages
1705-8
Notes
Journal Article --- Old month value: Dec
Résumé
This study was carried out to demonstrate the possible return of esophageal peristalsis in patients affected by esophageal achalasia chronically treated with sublingual nifedipine and to investigate which parameters are correlated with the return of peristalsis. Thirty-two patients were treated with sublingual nifedipine 10-20 mg taken 30 min before meals. A clinical and manometric evaluation was performed before and after 6 months of therapy. Before treatment, in no patient was peristaltic activity recorded. After 6 months, peristalsis was observed in six patients. In this group, no pretreatment manometric parameter was different from that of the remaining achalasic patients; only the clinical history of dysphagia was significantly shorter (p < 0.001) and the esophageal diameter significantly less (p < 0.001). In conclusion, chronic treatment with sublingual nifedipine can induce a return of esophageal peristalsis in patients with a short clinical history of disease and slightly dilated esophagus.
Mots-clé
Administration, Sublingual Adolescent Adult Aged Aged, 80 and over Deglutition/physiology Esophageal Achalasia/*drug therapy/physiopathology Esophagus/*physiopathology Female Humans Male Manometry Middle Aged Muscle Tonus/drug effects/physiology Nifedipine/*therapeutic use Peristalsis/drug effects/physiology
Pubmed
Web of science
Création de la notice
25/01/2008 17:02
Dernière modification de la notice
20/08/2019 17:11
Données d'usage