A phase 1 trial of adoptive transfer of vaccine-primed autologous circulating T cells in ovarian cancer.
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UNIL restricted access
State: Public
Version: author
License: Not specified
Serval ID
serval:BIB_E6692BB52E6C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A phase 1 trial of adoptive transfer of vaccine-primed autologous circulating T cells in ovarian cancer.
Journal
Nature cancer
ISSN
2662-1347 (Electronic)
ISSN-L
2662-1347
Publication state
Published
Issued date
10/2023
Peer-reviewed
Oui
Volume
4
Number
10
Pages
1410-1417
Language
english
Notes
Publication types: Clinical Trial, Phase I ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
We have previously shown that vaccination with tumor-pulsed dendritic cells amplifies neoantigen recognition in ovarian cancer. Here, in a phase 1 clinical study ( NCT01312376 /UPCC26810) including 19 patients, we show that such responses are further reinvigorated by subsequent adoptive transfer of vaccine-primed, ex vivo-expanded autologous peripheral blood T cells. The treatment is safe, and epitope spreading with novel neopeptide reactivities was observed after cell infusion in patients who experienced clinical benefit, suggesting reinvigoration of tumor-sculpting immunity.
Keywords
Humans, Female, Ovarian Neoplasms/therapy, Vaccines, Adoptive Transfer, Vaccination, T-Lymphocytes
Pubmed
Create date
25/09/2023 15:33
Last modification date
14/08/2024 6:17