A phase 1 trial of adoptive transfer of vaccine-primed autologous circulating T cells in ovarian cancer.
Détails
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Accès restreint UNIL
Etat: Public
Version: de l'auteur⸱e
Licence: Non spécifiée
Accès restreint UNIL
Etat: Public
Version: de l'auteur⸱e
Licence: Non spécifiée
ID Serval
serval:BIB_E6692BB52E6C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A phase 1 trial of adoptive transfer of vaccine-primed autologous circulating T cells in ovarian cancer.
Périodique
Nature cancer
ISSN
2662-1347 (Electronic)
ISSN-L
2662-1347
Statut éditorial
Publié
Date de publication
10/2023
Peer-reviewed
Oui
Volume
4
Numéro
10
Pages
1410-1417
Langue
anglais
Notes
Publication types: Clinical Trial, Phase I ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
We have previously shown that vaccination with tumor-pulsed dendritic cells amplifies neoantigen recognition in ovarian cancer. Here, in a phase 1 clinical study ( NCT01312376 /UPCC26810) including 19 patients, we show that such responses are further reinvigorated by subsequent adoptive transfer of vaccine-primed, ex vivo-expanded autologous peripheral blood T cells. The treatment is safe, and epitope spreading with novel neopeptide reactivities was observed after cell infusion in patients who experienced clinical benefit, suggesting reinvigoration of tumor-sculpting immunity.
Mots-clé
Humans, Female, Ovarian Neoplasms/therapy, Vaccines, Adoptive Transfer, Vaccination, T-Lymphocytes
Pubmed
Création de la notice
25/09/2023 15:33
Dernière modification de la notice
14/08/2024 6:17