Machine learning (ML) was used to predict contact ( ) and flight ( ) time, duty factor (DF) and peak vertical force ( ) from IMU-based estimations. One hundred runners ran on an instrumented treadmill (9-13 km/h) while wearing a sacral-mounted IMU. Linear regression (LR), support vector regression and two-layer neural-network were trained (80 participants) using IMU-based estimations, running speed, stride frequency and body mass. Predictions (remaining 20 participants) were compared to gold standard (kinetic data collected using the force plate) by calculating the mean absolute percentage error (MAPE). MAPEs of did not significantly differ among its estimation and predictions (P = 0.37), while prediction MAPEs for , and DF were significantly smaller than corresponding estimation MAPEs (P ≤ 0.003). There were no significant differences among prediction MAPEs obtained from the three ML models (P ≥ 0.80). Errors of the ML models were equal to or smaller than (≤32%) the smallest real difference for the four variables, while errors of the estimations were not (15-45%), indicating that ML models were sufficiently accurate to detect a clinically important difference. The simplest ML model (LR) should be used to improve the accuracy of the IMU-based estimations. These improvements may be beneficial when monitoring running-related injury risk factors in real-world settings.