Nonfatal prolonged overdosage of pyrimethamine in an infant: measurement of plasma and urine levels using HPLC with diode-array detection.
Details
Serval ID
serval:BIB_E547E1831ED9
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Nonfatal prolonged overdosage of pyrimethamine in an infant: measurement of plasma and urine levels using HPLC with diode-array detection.
Journal
Journal of Analytical Toxicology
ISSN
0146-4760[print], 0146-4760[linking]
Publication state
Published
Issued date
1993
Volume
17
Number
4
Pages
248-250
Language
english
Abstract
A nonfatal case of accidental prolonged overdosage of pyrimethamine (10 times the usual dose for 10 days) in a seven-week-old infant treated for congenital toxoplasmosis is presented. The drug was identified and quantitated in plasma and urine using an HPLC technique with diode-array detection. Initial plasma concentration of pyrimethamine was 6.22 micrograms/mL. Results are discussed in light of the existing literature.
Keywords
Chromatography, High Pressure Liquid, Female, Humans, Infant, Overdose, Pyrimethamine/analysis, Pyrimethamine/blood, Spectrophotometry, Toxoplasmosis, Congenital/drug therapy
Pubmed
Create date
18/10/2010 14:09
Last modification date
20/08/2019 16:08
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