Nonfatal prolonged overdosage of pyrimethamine in an infant: measurement of plasma and urine levels using HPLC with diode-array detection.

Détails

ID Serval
serval:BIB_E547E1831ED9
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Nonfatal prolonged overdosage of pyrimethamine in an infant: measurement of plasma and urine levels using HPLC with diode-array detection.
Périodique
Journal of Analytical Toxicology
Auteur(s)
Tracqui A., Mikail I., Kintz P., Mangin P.
ISSN
0146-4760[print], 0146-4760[linking]
Statut éditorial
Publié
Date de publication
1993
Volume
17
Numéro
4
Pages
248-250
Langue
anglais
Résumé
A nonfatal case of accidental prolonged overdosage of pyrimethamine (10 times the usual dose for 10 days) in a seven-week-old infant treated for congenital toxoplasmosis is presented. The drug was identified and quantitated in plasma and urine using an HPLC technique with diode-array detection. Initial plasma concentration of pyrimethamine was 6.22 micrograms/mL. Results are discussed in light of the existing literature.
Mots-clé
Chromatography, High Pressure Liquid, Female, Humans, Infant, Overdose, Pyrimethamine/analysis, Pyrimethamine/blood, Spectrophotometry, Toxoplasmosis, Congenital/drug therapy
Pubmed
Création de la notice
18/10/2010 14:09
Dernière modification de la notice
20/08/2019 16:08
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