Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting.

Details

Serval ID
serval:BIB_E4192A2ADCC3
Type
Article: article from journal or magazin.
Collection
Publications
Title
Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting.
Journal
FEBS Letters
Author(s)
Jimenez M., Léger B., Canola K., Lehr L., Arboit P., Seydoux J., Russell A.P., Giacobino J.P., Muzzin P., Preitner F.
ISSN
0014-5793 (Print)
ISSN-L
0014-5793
Publication state
Published
Issued date
2002
Volume
530
Number
1-3
Pages
37-40
Language
english
Abstract
Catecholamines are viewed as major stimulants of diet- and cold-induced thermogenesis and of fasting-induced lipolysis, through the beta-adrenoceptors (beta(1)/beta(2)/beta(3)). To test this hypothesis, we generated beta(1)/beta(2)/beta(3)-adrenoceptor triple knockout (TKO) mice and compared them to wild type animals. TKO mice exhibited normophagic obesity and cold-intolerance. Their brown fat had impaired morphology and lacked responses to cold of uncoupling protein-1 expression. In contrast, TKO mice had higher circulating levels of free fatty acids and glycerol at basal and fasted states, suggesting enhanced lipolysis. Hence, beta-adrenergic signalling is essential for the resistance to obesity and cold, but not for the lipolytic response to fasting.
Keywords
Adipose Tissue, Brown/physiopathology, Animals, Blotting, Western, Cold Temperature, Lipolysis, Mice, Mice, Knockout, Obesity/genetics, Obesity/physiopathology, Receptors, Adrenergic, beta-1/genetics, Receptors, Adrenergic, beta-1/physiology, Receptors, Adrenergic, beta-2/genetics, Receptors, Adrenergic, beta-2/physiology, Receptors, Adrenergic, beta-3/genetics, Receptors, Adrenergic, beta-3/physiology, Sensory Thresholds, Starvation
Pubmed
Web of science
Open Access
Yes
Create date
18/12/2012 15:50
Last modification date
20/08/2019 16:07
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