Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting.

Détails

ID Serval
serval:BIB_E4192A2ADCC3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting.
Périodique
FEBS Letters
Auteur(s)
Jimenez M., Léger B., Canola K., Lehr L., Arboit P., Seydoux J., Russell A.P., Giacobino J.P., Muzzin P., Preitner F.
ISSN
0014-5793 (Print)
ISSN-L
0014-5793
Statut éditorial
Publié
Date de publication
2002
Volume
530
Numéro
1-3
Pages
37-40
Langue
anglais
Résumé
Catecholamines are viewed as major stimulants of diet- and cold-induced thermogenesis and of fasting-induced lipolysis, through the beta-adrenoceptors (beta(1)/beta(2)/beta(3)). To test this hypothesis, we generated beta(1)/beta(2)/beta(3)-adrenoceptor triple knockout (TKO) mice and compared them to wild type animals. TKO mice exhibited normophagic obesity and cold-intolerance. Their brown fat had impaired morphology and lacked responses to cold of uncoupling protein-1 expression. In contrast, TKO mice had higher circulating levels of free fatty acids and glycerol at basal and fasted states, suggesting enhanced lipolysis. Hence, beta-adrenergic signalling is essential for the resistance to obesity and cold, but not for the lipolytic response to fasting.
Mots-clé
Adipose Tissue, Brown/physiopathology, Animals, Blotting, Western, Cold Temperature, Lipolysis, Mice, Mice, Knockout, Obesity/genetics, Obesity/physiopathology, Receptors, Adrenergic, beta-1/genetics, Receptors, Adrenergic, beta-1/physiology, Receptors, Adrenergic, beta-2/genetics, Receptors, Adrenergic, beta-2/physiology, Receptors, Adrenergic, beta-3/genetics, Receptors, Adrenergic, beta-3/physiology, Sensory Thresholds, Starvation
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/12/2012 15:50
Dernière modification de la notice
20/08/2019 16:07
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