Extraintestinal manifestations in inflammatory bowel disease: frequency and associated risk factors in the nationwide Swiss IBD cohort study (SIBDCS)
Details
Serval ID
serval:BIB_E33DBA70ABBA
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Extraintestinal manifestations in inflammatory bowel disease: frequency and associated risk factors in the nationwide Swiss IBD cohort study (SIBDCS)
Title of the conference
Annual Meeting of the Swiss Society of Gastroenterology, Swiss Society for Visceral Surgery, Swiss Association for the Study of the Liver, Swiss Association of Clinical Nutrition
Address
Interlaken, Switzerland, September 23-24, 2010
ISBN
1424-7860
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
140
Series
Swiss Medical Weekly
Pages
13S
Language
english
Notes
[Poster]
http://www.smw.ch/fileadmin/smw/pdf/Supplementa_2010/smw_Suppl-183.pdf
http://www.smw.ch/fileadmin/smw/pdf/Supplementa_2010/smw_Suppl-183.pdf
Abstract
Background: Data on the frequency of extraintestinal
manifestations (EIM) in Crohnʼs disease (CD) and ulcerative
colitis (UC) are scarce. Goal: to evaluate prevalences, forms of
EIM and risk factors in a large nationwide IBD cohort.
Methods: Data from validated physician enrolment
questionnaires of the adult Swiss IBD cohort were analyzed.
Logistic regression models were used to identify EIM risk
factors.
Results: 950 patients were included, 580 (61%) with
CD (mean age 43yrs) and 370 (39%) with UC (mean age
49yrs), of these, 249 (43%) of CD and 113 (31%) of UC patients
had one to 5 EIM. The following EIM were found: arthritis (CD
33%, UC 21%), aphthous stomatitis (CD 10%, UC 4%), uveitis
(CD 6%, UC 4%), erythema nodosum (CD 6%, UC 3%),
ankylosing spondylitis (CD 6%, UC 2%), psoriasis (CD 2%, UC
1%), pyoderma gangrenosum (CD and UC each 2%), primary
sclerosing cholangitis (CD 1%, UC 4%). Logistic regression in
CD identified the following items as risk factors for ongoing EIM:
active disease (OR 1.95, 95% CI 1.17-3.23, P=0.01), positive
IBD family history (OR 1.77, 95% CI 1.07-2.92, P=0.025). No
risk factors were identified in UC patients.
Conclusions: EIM
are a frequent problem in CD and UC patients. Active disease
and positive IBD family history are associated with ongoing EIM
in CD patients. Identification of EIM prevalence and associated
risk factors may result in increased awareness for this problem
and thereby facilitate their diagnosis and management.
manifestations (EIM) in Crohnʼs disease (CD) and ulcerative
colitis (UC) are scarce. Goal: to evaluate prevalences, forms of
EIM and risk factors in a large nationwide IBD cohort.
Methods: Data from validated physician enrolment
questionnaires of the adult Swiss IBD cohort were analyzed.
Logistic regression models were used to identify EIM risk
factors.
Results: 950 patients were included, 580 (61%) with
CD (mean age 43yrs) and 370 (39%) with UC (mean age
49yrs), of these, 249 (43%) of CD and 113 (31%) of UC patients
had one to 5 EIM. The following EIM were found: arthritis (CD
33%, UC 21%), aphthous stomatitis (CD 10%, UC 4%), uveitis
(CD 6%, UC 4%), erythema nodosum (CD 6%, UC 3%),
ankylosing spondylitis (CD 6%, UC 2%), psoriasis (CD 2%, UC
1%), pyoderma gangrenosum (CD and UC each 2%), primary
sclerosing cholangitis (CD 1%, UC 4%). Logistic regression in
CD identified the following items as risk factors for ongoing EIM:
active disease (OR 1.95, 95% CI 1.17-3.23, P=0.01), positive
IBD family history (OR 1.77, 95% CI 1.07-2.92, P=0.025). No
risk factors were identified in UC patients.
Conclusions: EIM
are a frequent problem in CD and UC patients. Active disease
and positive IBD family history are associated with ongoing EIM
in CD patients. Identification of EIM prevalence and associated
risk factors may result in increased awareness for this problem
and thereby facilitate their diagnosis and management.
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Create date
02/02/2011 11:30
Last modification date
20/08/2019 17:07
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