Extraintestinal manifestations in inflammatory bowel disease: frequency and associated risk factors in the nationwide Swiss IBD cohort study (SIBDCS)
Détails
ID Serval
serval:BIB_E33DBA70ABBA
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Institution
Titre
Extraintestinal manifestations in inflammatory bowel disease: frequency and associated risk factors in the nationwide Swiss IBD cohort study (SIBDCS)
Titre de la conférence
Annual Meeting of the Swiss Society of Gastroenterology, Swiss Society for Visceral Surgery, Swiss Association for the Study of the Liver, Swiss Association of Clinical Nutrition
Adresse
Interlaken, Switzerland, September 23-24, 2010
ISBN
1424-7860
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
140
Série
Swiss Medical Weekly
Pages
13S
Langue
anglais
Notes
[Poster]
http://www.smw.ch/fileadmin/smw/pdf/Supplementa_2010/smw_Suppl-183.pdf
http://www.smw.ch/fileadmin/smw/pdf/Supplementa_2010/smw_Suppl-183.pdf
Résumé
Background: Data on the frequency of extraintestinal
manifestations (EIM) in Crohnʼs disease (CD) and ulcerative
colitis (UC) are scarce. Goal: to evaluate prevalences, forms of
EIM and risk factors in a large nationwide IBD cohort.
Methods: Data from validated physician enrolment
questionnaires of the adult Swiss IBD cohort were analyzed.
Logistic regression models were used to identify EIM risk
factors.
Results: 950 patients were included, 580 (61%) with
CD (mean age 43yrs) and 370 (39%) with UC (mean age
49yrs), of these, 249 (43%) of CD and 113 (31%) of UC patients
had one to 5 EIM. The following EIM were found: arthritis (CD
33%, UC 21%), aphthous stomatitis (CD 10%, UC 4%), uveitis
(CD 6%, UC 4%), erythema nodosum (CD 6%, UC 3%),
ankylosing spondylitis (CD 6%, UC 2%), psoriasis (CD 2%, UC
1%), pyoderma gangrenosum (CD and UC each 2%), primary
sclerosing cholangitis (CD 1%, UC 4%). Logistic regression in
CD identified the following items as risk factors for ongoing EIM:
active disease (OR 1.95, 95% CI 1.17-3.23, P=0.01), positive
IBD family history (OR 1.77, 95% CI 1.07-2.92, P=0.025). No
risk factors were identified in UC patients.
Conclusions: EIM
are a frequent problem in CD and UC patients. Active disease
and positive IBD family history are associated with ongoing EIM
in CD patients. Identification of EIM prevalence and associated
risk factors may result in increased awareness for this problem
and thereby facilitate their diagnosis and management.
manifestations (EIM) in Crohnʼs disease (CD) and ulcerative
colitis (UC) are scarce. Goal: to evaluate prevalences, forms of
EIM and risk factors in a large nationwide IBD cohort.
Methods: Data from validated physician enrolment
questionnaires of the adult Swiss IBD cohort were analyzed.
Logistic regression models were used to identify EIM risk
factors.
Results: 950 patients were included, 580 (61%) with
CD (mean age 43yrs) and 370 (39%) with UC (mean age
49yrs), of these, 249 (43%) of CD and 113 (31%) of UC patients
had one to 5 EIM. The following EIM were found: arthritis (CD
33%, UC 21%), aphthous stomatitis (CD 10%, UC 4%), uveitis
(CD 6%, UC 4%), erythema nodosum (CD 6%, UC 3%),
ankylosing spondylitis (CD 6%, UC 2%), psoriasis (CD 2%, UC
1%), pyoderma gangrenosum (CD and UC each 2%), primary
sclerosing cholangitis (CD 1%, UC 4%). Logistic regression in
CD identified the following items as risk factors for ongoing EIM:
active disease (OR 1.95, 95% CI 1.17-3.23, P=0.01), positive
IBD family history (OR 1.77, 95% CI 1.07-2.92, P=0.025). No
risk factors were identified in UC patients.
Conclusions: EIM
are a frequent problem in CD and UC patients. Active disease
and positive IBD family history are associated with ongoing EIM
in CD patients. Identification of EIM prevalence and associated
risk factors may result in increased awareness for this problem
and thereby facilitate their diagnosis and management.
Web of science
Création de la notice
02/02/2011 10:30
Dernière modification de la notice
20/08/2019 16:07
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