Article: article from journal or magazin.
Prospective determination of plasma imipenem concentrations in critically ill children.
Antimicrobial Agents and Chemotherapy
Plasma imipenem concentrations were measured in 19 critically ill children (median age, 0.8 year; range, 0.02 to 12.9 years). Wide interindividual variations (2 to 4x at peak and >10x at trough concentrations) resulted in unpredictable plasma levels in several children. To avoid subtherapeutic drug levels, we recommend treatment with at least 100 mg/kg of body weight/day of imipenem-cilastatin for critically ill children requiring such therapy.
Anti-Bacterial Agents/administration & dosage, Area Under Curve, Bacterial Infections/drug therapy, Bacterial Infections/microbiology, Child, Child, Preschool, Cilastatin/administration & dosage, Critical Illness, Cross Infection/drug therapy, Cross Infection/microbiology, Drug Combinations, Drug Therapy, Combination, Female, Humans, Imipenem/administration & dosage, Imipenem/pharmacokinetics, Infant, Infant, Newborn, Infusions, Intravenous, Male
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