Prospective determination of plasma imipenem concentrations in critically ill children.

Détails

ID Serval
serval:BIB_E2F1AB540BD5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Prospective determination of plasma imipenem concentrations in critically ill children.
Périodique
Antimicrobial Agents and Chemotherapy
Auteur(s)
Giannoni E., Moreillon P., Cotting J., Moessinger A., Bille J., Décosterd L., Zanetti G., Majcherczyk P., Bugnon D.
ISSN
0066-4804[print], 0066-4804[linking]
Statut éditorial
Publié
Date de publication
2006
Volume
50
Numéro
7
Pages
2563-2568
Langue
anglais
Résumé
Plasma imipenem concentrations were measured in 19 critically ill children (median age, 0.8 year; range, 0.02 to 12.9 years). Wide interindividual variations (2 to 4x at peak and >10x at trough concentrations) resulted in unpredictable plasma levels in several children. To avoid subtherapeutic drug levels, we recommend treatment with at least 100 mg/kg of body weight/day of imipenem-cilastatin for critically ill children requiring such therapy.
Mots-clé
Anti-Bacterial Agents/administration & dosage, Area Under Curve, Bacterial Infections/drug therapy, Bacterial Infections/microbiology, Child, Child, Preschool, Cilastatin/administration & dosage, Critical Illness, Cross Infection/drug therapy, Cross Infection/microbiology, Drug Combinations, Drug Therapy, Combination, Female, Humans, Imipenem/administration & dosage, Imipenem/pharmacokinetics, Infant, Infant, Newborn, Infusions, Intravenous, Male
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 13:54
Dernière modification de la notice
20/08/2019 16:06
Données d'usage