Prospective determination of plasma imipenem concentrations in critically ill children.
Details
Serval ID
serval:BIB_E2F1AB540BD5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prospective determination of plasma imipenem concentrations in critically ill children.
Journal
Antimicrobial Agents and Chemotherapy
ISSN
0066-4804[print], 0066-4804[linking]
Publication state
Published
Issued date
2006
Volume
50
Number
7
Pages
2563-2568
Language
english
Abstract
Plasma imipenem concentrations were measured in 19 critically ill children (median age, 0.8 year; range, 0.02 to 12.9 years). Wide interindividual variations (2 to 4x at peak and >10x at trough concentrations) resulted in unpredictable plasma levels in several children. To avoid subtherapeutic drug levels, we recommend treatment with at least 100 mg/kg of body weight/day of imipenem-cilastatin for critically ill children requiring such therapy.
Keywords
Anti-Bacterial Agents/administration & dosage, Area Under Curve, Bacterial Infections/drug therapy, Bacterial Infections/microbiology, Child, Child, Preschool, Cilastatin/administration & dosage, Critical Illness, Cross Infection/drug therapy, Cross Infection/microbiology, Drug Combinations, Drug Therapy, Combination, Female, Humans, Imipenem/administration & dosage, Imipenem/pharmacokinetics, Infant, Infant, Newborn, Infusions, Intravenous, Male
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 14:54
Last modification date
20/08/2019 17:06