Prospective determination of plasma imipenem concentrations in critically ill children.

Details

Serval ID
serval:BIB_E2F1AB540BD5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prospective determination of plasma imipenem concentrations in critically ill children.
Journal
Antimicrobial Agents and Chemotherapy
Author(s)
Giannoni E., Moreillon P., Cotting J., Moessinger A., Bille J., Décosterd L., Zanetti G., Majcherczyk P., Bugnon D.
ISSN
0066-4804[print], 0066-4804[linking]
Publication state
Published
Issued date
2006
Volume
50
Number
7
Pages
2563-2568
Language
english
Abstract
Plasma imipenem concentrations were measured in 19 critically ill children (median age, 0.8 year; range, 0.02 to 12.9 years). Wide interindividual variations (2 to 4x at peak and >10x at trough concentrations) resulted in unpredictable plasma levels in several children. To avoid subtherapeutic drug levels, we recommend treatment with at least 100 mg/kg of body weight/day of imipenem-cilastatin for critically ill children requiring such therapy.
Keywords
Anti-Bacterial Agents/administration & dosage, Area Under Curve, Bacterial Infections/drug therapy, Bacterial Infections/microbiology, Child, Child, Preschool, Cilastatin/administration & dosage, Critical Illness, Cross Infection/drug therapy, Cross Infection/microbiology, Drug Combinations, Drug Therapy, Combination, Female, Humans, Imipenem/administration & dosage, Imipenem/pharmacokinetics, Infant, Infant, Newborn, Infusions, Intravenous, Male
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 14:54
Last modification date
20/08/2019 17:06
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