Fitness cost and impaired survival in penicillin-resistant Streptococcus gordonii isolates selected in the laboratory.
Details
Serval ID
serval:BIB_E2D1A8A9A1D3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Fitness cost and impaired survival in penicillin-resistant Streptococcus gordonii isolates selected in the laboratory.
Journal
Antimicrobial Agents and Chemotherapy
ISSN
0066-4804[print], 0066-4804[linking]
Publication state
Published
Issued date
2008
Volume
52
Number
1
Pages
337-339
Language
english
Abstract
Cycling of Streptococcus gordonii (115 times) with penicillin resulted in a MIC increase of more than 100-fold, from 0.008 to 2 microg/ml. The 2-microg/ml MIC maximum was already reached after 36 passages but resulted in impaired fitness. Although the MIC did not increase further, fitness was partially recovered during the 79 additional cycles.
Keywords
Anti-Bacterial Agents/pharmacology, Microbial Sensitivity Tests, Mutation, Penicillin Resistance/genetics, Penicillins/pharmacology, Selection, Genetic, Serial Passage, Streptococcus gordonii/drug effects, Streptococcus gordonii/genetics
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 14:58
Last modification date
20/08/2019 17:06
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