Fitness cost and impaired survival in penicillin-resistant Streptococcus gordonii isolates selected in the laboratory.
Détails
ID Serval
serval:BIB_E2D1A8A9A1D3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Fitness cost and impaired survival in penicillin-resistant Streptococcus gordonii isolates selected in the laboratory.
Périodique
Antimicrobial Agents and Chemotherapy
ISSN
0066-4804[print], 0066-4804[linking]
Statut éditorial
Publié
Date de publication
2008
Volume
52
Numéro
1
Pages
337-339
Langue
anglais
Résumé
Cycling of Streptococcus gordonii (115 times) with penicillin resulted in a MIC increase of more than 100-fold, from 0.008 to 2 microg/ml. The 2-microg/ml MIC maximum was already reached after 36 passages but resulted in impaired fitness. Although the MIC did not increase further, fitness was partially recovered during the 79 additional cycles.
Mots-clé
Anti-Bacterial Agents/pharmacology, Microbial Sensitivity Tests, Mutation, Penicillin Resistance/genetics, Penicillins/pharmacology, Selection, Genetic, Serial Passage, Streptococcus gordonii/drug effects, Streptococcus gordonii/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 13:58
Dernière modification de la notice
20/08/2019 16:06
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