Optogenetic Interrogation of Dopaminergic Modulation of the Multiple Phases of Reward-Seeking Behavior.

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Serval ID
serval:BIB_E265886CC42B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Optogenetic Interrogation of Dopaminergic Modulation of the Multiple Phases of Reward-Seeking Behavior.
Journal
Journal of Neuroscience
Author(s)
Adamantidis A.R., Tsai H.C., Boutrel B., Zhang F., Stuber G.D., Budygin E.A., Touriño C., Bonci A., Deisseroth K., de Lecea L.
ISSN
1529-2401 (Electronic)
ISSN-L
0270-6474
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
31
Number
30
Pages
10829-10835
Language
english
Notes
Publication types: JOURNAL ARTICLE Publication Status: ppublish
Abstract
Phasic activation of dopaminergic neurons is associated with reward-predicting cues and supports learning during behavioral adaptation. While noncontingent activation of dopaminergic neurons in the ventral tegmental are (VTA) is sufficient for passive behavioral conditioning, it remains unknown whether the phasic dopaminergic signal is truly reinforcing. In this study, we first targeted the expression of channelrhodopsin-2 to dopaminergic neurons of the VTA and optimized optogenetically evoked dopamine transients. Second, we showed that phasic activation of dopaminergic neurons in freely moving mice causally enhances positive reinforcing actions in a food-seeking operant task. Interestingly, such effect was not found in the absence of food reward. We further found that phasic activation of dopaminergic neurons is sufficient to reactivate previously extinguished food-seeking behavior in the absence of external cues. This was also confirmed using a single-session reversal paradigm. Collectively, these data suggest that activation of dopaminergic neurons facilitates the development of positive reinforcement during reward-seeking and behavioral flexibility.
Pubmed
Web of science
Open Access
Yes
Create date
22/08/2011 11:10
Last modification date
20/08/2019 16:06
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